Title of article
Optimization of novel combi-molecules: Identification of balanced and mixed bcr-abl/DNA targeting properties
Author/Authors
Zakaria Rachid، نويسنده , , Athanasia Katsoulas، نويسنده , , Christopher Williams، نويسنده , , Anne-Laure Larroque، نويسنده , , James McNamee، نويسنده , , Bertrand J. Jean-Claude، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
4248
To page
4253
Abstract
Steps toward the identification of combi-molecules with strong abl tyrosine kinase (TK) inhibitory property and significant DNA damaging potential are described. The optimized combi-molecule 13a was shown to induce approximately twofold stronger abl TK inhibitory activity than Gleevec™ and high levels of DNA damage in chronic myelogenous leukemic cells.
Keywords
Triazene , CML , Pyridopyrimidine , Combi-molecule , chronic myelogenous leukemia , Gleevec , BCR-ABL , inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798403
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