Title of article
N4-Phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease
Author/Authors
Wenwei Huang، نويسنده , , Wei Zheng، نويسنده , , Daniel J. Urban، نويسنده , , James Inglese، نويسنده , , Ellen Sidransky، نويسنده , , Christopher P. Austin، نويسنده , , Craig J. Thomas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
5783
To page
5789
Abstract
A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related sugar hydrolases enzymes are described.
Keywords
Gaucher disease , Triazine , Glucocerebrosidase , Chemical chaperone
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798697
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