Title of article
A novel class of potent NF-κB signaling inhibitors
Author/Authors
Johann Leban، نويسنده , , Marcel Baierl، نويسنده , , Jan Mies، نويسنده , , Viola Trentinaglia، نويسنده , , Sandra Rath، نويسنده , , Kerstin Kronthaler، نويسنده , , Kristina Wolf، نويسنده , , Astrid Gotschlich، نويسنده , , Markus H.J. Seifert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5858
To page
5862
Abstract
A novel class of NF-κB pathway signaling inhibitors was discovered by virtual screening, medicinal chemistry, and QSAR analysis. An initial set of compounds inhibited NF-κB signaling in a whole cell reporter gene assay in the micro-molar range. Activity was improved step by step by medicinal chemistry to yield nano-molar signaling inhibitors.
Keywords
NF-?B , nuclear factor ?B , signaling , inhibitor , Anti-viral , anti-inflammatory
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798709
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