Title of article
The discovery of indole-derived long acting β2-adrenoceptor agonists for the treatment of asthma and COPD
Author/Authors
Alan D. Brown، نويسنده , , Mark E. Bunnage، نويسنده , , Paul A. Glossop، نويسنده , , Mark Holbrook، نويسنده , , Rhys D. Jones، نويسنده , , Charlotte A.L. Lane، نويسنده , , Russell A. Lewthwaite، نويسنده , , Simon Mantell، نويسنده , , Christelle Perros-Huguet، نويسنده , , David A. Price، نويسنده , , Rob Webster، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
6188
To page
6191
Abstract
The design and profile of a series of indole containing long acting β2-adrenoceptor agonists is described. Evaluation of these analogues using an in vitro guinea pig trachea tissue model demonstrates that analogues within this series have salmeterol-like duration of action with potential for long duration of action in humans.
Keywords
indole , Long Acting , Beta-2 adrenoceptor agonist , COPD , asthma
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798772
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