Title of article
Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation
Author/Authors
N.R. Thimmegowda، نويسنده , , S. Nanjunda Swamy، نويسنده , , C.S. Ananda Kumar، نويسنده , , Y.C. Sunil Kumar، نويسنده , , S. Chandrappa، نويسنده , , George W. Yip، نويسنده , , K.S. Rangappa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
432
To page
435
Abstract
A novel series of trisubstituted benzimidazole and its precursors (3–7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (3) was the potent inhibitor.
Keywords
Trisubstituted benzimidazole , MDA-MB-231 , cell proliferation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798993
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