Title of article
Radiosyntheses of two positron emission tomography probes: [11C]Oseltamivir and its active metabolite [11C]Ro 64-0802
Author/Authors
Fujiko Konno، نويسنده , , Takuya Arai، نويسنده , , Ming-Rong Zhang، نويسنده , , Akiko Hatori، نويسنده , , Kazuhiko Yanamoto، نويسنده , , Masanao Ogawa، نويسنده , , Gukuto Ito، نويسنده , , Chika Odawara، نويسنده , , Tomoteru Yamasaki، نويسنده , , Koichi Kato، نويسنده , , Kazutoshi Suzuki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
1260
To page
1263
Abstract
Oseltamivir phosphate (Tamiflu®, 1•H3PO4 is an orally active anti-influenza drug, which is hydrolyzed by esterase to its carboxylate metabolite Ro 64-0802 (2) with potent activity inhibiting neuraminidase. In this study, for the first time, we synthesized carbon-11-labeled oseltamivir ([11C]1) and Ro 64-0802 ([11C]2) as two novel positron emission tomography probes and demonstrated that [11C]1 had twofold higher radioactivity concentration in the mouse brains than [11C]2.
Keywords
positron emission tomography
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799147
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