Title of article
Synthesis and anticancer activity studies of cyclopamine derivatives
Author/Authors
Jianjun Zhang، نويسنده , , Massoud Garrossian، نويسنده , , Dale Gardner، نويسنده , , Arash Garrossian، نويسنده , , Young Tae Chang، نويسنده , , Yun Kyung Kim، نويسنده , , Cheng-Wei Tom Chang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
1359
To page
1363
Abstract
A diversity-oriented synthesis has been developed for facile construction of a library of carbohydrate–cyclopamine conjugates. The synthetic protocol is suitable for generating cyclopamine derivatives with various structural motifs for exploring the desired activity. From this initial library, we have observed one derivative that exhibits improved activity against lung cancer cell as compared to cyclopamine.
Keywords
Cyclopamine , Carbohydrates , Hedgehog pathway , Bioconjugates
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799167
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