Title of article
New chemotypes for cathepsin K inhibitors
Author/Authors
Naoki Teno، نويسنده , , Osamu Irie، نويسنده , , Takahiro Miyake، نويسنده , , Keigo Gohda، نويسنده , , Miyuki Horiuchi، نويسنده , , Sachiyo Tada، نويسنده , , Kazuhiko Nonomura، نويسنده , , Motohiko Kometani، نويسنده , , Genji Iwasaki، نويسنده , , Claudia Betschart، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2599
To page
2603
Abstract
Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8.
Keywords
Non-peptidic inhibitors , Cathepsin K , New chemotype , Cyano pyrimidine t-amine , Cyano pryrimidine acetylene
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799409
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