Title of article :
Discovery of new Gram-negative antivirulence drugs: Structure and properties of novel E. coli WaaC inhibitors
Author/Authors :
F. Moreau، نويسنده , , N. Desroy، نويسنده , , J.M. Genevard، نويسنده , , V. Vongsouthi، نويسنده , , V. Gerusz، نويسنده , , G. Le Fralliec، نويسنده , , C. Oliveira، نويسنده , , S. Floquet، نويسنده , , A. Denis، نويسنده , , S. Escaich، نويسنده , , K. Wolf، نويسنده , , M. Busemann، نويسنده , , A. Aschenbrenner، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
5
From page :
4022
To page :
4026
Abstract :
Heptosyltransferases such as WaaC represent promising and attractive targets for the discovery of new Gram-negative antibacterial drugs based on antivirulence mechanisms. We report herein our approach to the identification of the first micromolar inhibitors of WaaC and the preliminary SAR generated from this family of 2-aryl-5-methyl-4-(5-aryl-furan-2-yl-methylene)-2,4-dihydro-pyrazol-3-ones identified by virtual screening.
Keywords :
Antivirulence drugs , WAAC , Anti-infective , E. coli , Glycosyltranferases , Virtual screening
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2008
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
799708
Link To Document :
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