Author/Authors :
Vivek Kumar، نويسنده , , Nidhi Rani، نويسنده , , Pawan Aggarwal، نويسنده , , Vinod K. Sanna، نويسنده , , Anu T. Singh، نويسنده , , Manu Jaggi، نويسنده , , Narendra Joshi، نويسنده , , Pramod K. Sharma، نويسنده , , Raghuveer Irchhaiya، نويسنده , , Anand C. Burman، نويسنده ,
Abstract :
A new series of betulinic acid derivatives have been synthesized by introducing heterocyclic ring between C-2 and C-3 positions of betulinic acid. Further modifications were also carried out by reduction of C-20(29) unsaturated bond and substitution of C-28 carboxyl group by ester and amide linkage to enhance the selectivity. Compound 11 resulted in IC50 of 2.44, 2.5, and 2.7 μg/ml on MIAPaCa, PA-1, and SW620 cancer cell lines, respectively. Compound 38 resulted in IC50 of 0.67 μg/ml on MIAPaCa cell line.