Title of article :
Synthesis and biodistribution of a novel 99mTcN complex of ciprofloxacin dithiocarbamate as a potential agent for infection imaging
Author/Authors :
Junbo Zhang، نويسنده , , Haixun Guo، نويسنده , , Shijian Zhang، نويسنده , , Yan Lin، نويسنده , , Xuebin Wang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
3
From page :
5168
To page :
5170
Abstract :
The ciprofloxacin dithiocarbamate (CPFXDTC) was synthesized and radiolabeled with [99mTcN]2+ intermediate to form the 99mTcN-CPFXDTC complex in high yield (>95%). No decomposition of the complex at room temperature was observed over a period of 6 h. Its partition coefficient indicated that it was a good lipophilic complex. The bacterial binding assay studies showed 99mTcN-CPFXDTC had a better binding affinity as compared with 99mTc-ciprofloxacin. Biodistribution results in induced infection mice showed 99mTcN-CPFXDTC had higher uptake at the sites of infection and better abscess/blood ratio than that of 99mTc-ciprofloxacin, suggesting 99mTcN-CPFXDTC would be a novel potential infection imaging agent.
Keywords :
Infection imaging , 99mTc nitrido complex , Dithiocarbamate , Ciprofloxacin
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2008
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
799971
Link To Document :
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