Title of article
Synthesis of α-helix mimetics with four side-chains
Author/Authors
Per Restorp، نويسنده , , Julius Rebek Jr.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
5909
To page
5911
Abstract
The synthesis of a heterocyclic piperazine-based scaffold that mimics the i, i + 4, i + 8, i + 11 side-chain projections of an α-helix is described. The synthesis is designed to be modular to allow the targeting of a range of protein–protein interactions involving α-helices.
Keywords
N-Arylation , Heterocycles , piperazines , Protein–protein interaction , Alfa-helix mimetics
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800136
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