Title of article
Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246
Author/Authors
Yoshihito Shiono، نويسنده , , Keiko Shimanuki، نويسنده , , Fuminori Hiramatsu، نويسنده , , Takuya Koseki، نويسنده , , Murayama Tetsuya، نويسنده , , Nozomi Fujisawa، نويسنده , , Kenichi Kimura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
6050
To page
6053
Abstract
Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher’s method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.
Keywords
Pyrrospirones , endophyte , Pyrrocidines , Neonectria ramulariae
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800167
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