Title of article
β-C-Glycosiduronic acids and β-C-glycosyl compounds: New PTP1B inhibitors
Author/Authors
Li Lin، نويسنده , , Qiang Shen، نويسنده , , Guorong Chen، نويسنده , , Li Juan Xie، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
6348
To page
6351
Abstract
β-C-Glycosiduronic acid quinones and β-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl β-C-glycosyl compounds (18, 22, 23 and 34) showed IC50 values of 0.77–5.27 μM against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent.
Keywords
inhibitor , Diabetes , C-Glycosyl compounds , Quinone , Uronic acid , Protein tyrosine phosphatase 1B
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800233
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