Title of article
New 5-HT1A receptor agonists possessing 1,4-Benzoxazepine scaffold exhibit highly potent anti-ischemic effects
Author/Authors
Katsuhide Kamei، نويسنده , , Noriko Maeda، نويسنده , , Ryoko Ogino، نويسنده , , Makoto Koyama، نويسنده , , Mika Nakajima، نويسنده , , Toshio Tatsuoka، نويسنده , , Tomochika Ohno، نويسنده , , Teruyoshi Inoue، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
595
To page
598
Abstract
A series of new 3-substituted-4-(4-aminobutyl)-1,4-benzoxazepin-5(4H)-one derivatives (1–5) which showed a very high affinity for 5-HT1A receptor with good selectivity over dopamine D2 receptor was synthesized. Among these compounds, 3-chloro-4-[4-[4-(2-pyridinyl)-1,2,3,6-tetrahydropyridin-1-yl]butyl]-1,4-benzoxazepin-5(4H)-one (5: SUN N4057) exhibited remarkable neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800403
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