Author/Authors :
Nooraei، Navid نويسنده Department of Anesthesiology, Shahid Beheshti University of Medical Sciences , , Ebrahimi Dehkordi، Masih نويسنده Department of Anesthesiology, Shahid Beheshti University of Medical Sciences , , Radpay، Badiozaman نويسنده , , Teimoorian، Hooman نويسنده Department of Anesthesiology, Shahid Beheshti University of Medical Sciences , , Mohajerani، Seyed Amir نويسنده Department of Anesthesiology, Mofid Pediatric Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,
Abstract :
Background: Laryngoscopy and intubation incur hemodynamic changes like
increase in heart rate, arterial blood pressure, pulmonary artery pressure,
wedge capillary pressure and arrhythmias. Anesthesiologists are continually in
search of ways to alleviate such complications. Several medicinal methods have
been suggested that serve the purpose including the administration of
intravenous magnesium sulfate to minimize these unfavorable responses. This
study compares the effects of intravenous administration of lidocaine and
magnesium sulfate on unwanted hemodynamic responses following
laryngoscopy and intubation in elective surgery candidates.
Materials and Methods: This randomized double-blind clinical trial was
conducted on 60 ASA-I and ASA-II candidates who received 60 mg/kg (based
on Lean Body Mass) magnesium sulfate or lidocaine randomly before
intubation. Values of systolic and diastolic blood pressures, mean arterial
pressure, and heart rate were recorded for both groups during the 5 minutes
following administration, and compared with baseline values.
Results: In both groups, systolic blood pressure increased compared to the
baseline value. However, there was a significant difference between the two
groups as this increase occurred within the first 3 minutes in the lidocaine
group, while within the first minute in the magnesium sulfate group. The
increase in diastolic blood pressure was not significant. But there was a
significant difference in the mean arterial pressure increase between the two
groups since in the magnesium sulfate group this increase occurred in the first
minute whereas in the lidocaine group it occurred during the first two minutes.
There was no significant difference in the heart rates after intubation between
the two groups.
Conclusion: Magnesium sulfate is more effective than lidocaine in controlling
hemodynamics, although it may increase the heart rate.
