Title of article :
Synthesis of dehydroabietic acid-modified chitosan and its drug release behavior Original Research Article
Author/Authors :
Wengui Duan، نويسنده , , Changmao Shen، نويسنده , , Huaxiang Fang، نويسنده , , Guang Hua Li، نويسنده ,
Issue Information :
دوهفته نامه با شماره پیاپی سال 2009
Abstract :
A new type of chitosan derivative, dehydroabietic acid-modified chitosan (DAMC), was synthesized by the acylation reaction of chitosan with dehydroabietic acid chloride (DHAC) under microwave irradiation. The resulting product (DAMC) was characterized by FT-IR, UV, 1H NMR, X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), and elemental analysis. The degree of substitution (DS) of DAMC was 16.5%. And chitosan and DAMC were used as carriers of fenoprofen calcium (FC), and their controlled release behavior in artificial intestinal juice was studied. The results showed that the controlled release of FC from the carrier of DAMC is better than that from original chitosan.
Keywords :
Microwave , Drug release , Dehydroabietic acid , Chitosan , Acylation reaction
Journal title :
Carbohydrate Research
Journal title :
Carbohydrate Research