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PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUK_IN-IO FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION

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Interleukin-10 (lL-10) is a potent immunosuppressor which inhibits alloantigenic T cell response. IL-10 is also an anti-inflammatory endogenous cytokine. To investigate the predictive significance of endogenous IL-1 0 for acute graft versus host disease (GVHD) following allogeneic bone marrow transplantation (BMT), we performed a prospective study on spontaneous IL-10 production in the senlm of 96 patients admitted for allogeneic BMT. High spontaneous IL-1 0 production at the time of admission and prior to any preparative treatment correlates with a subsequent low incidence of G\THD as compared to patients with low IL-IO production. Our data demonstrate the predictive significance of increased IL-10 production in BMT patients and suggest a role for it in maintaining immunobalance in the setting of allogenic BMT.

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