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Organotin(IV) Derivatives as Biocides: An Investigation of Structure by IR, Solution NMR, Electron Impact MS and Assessment of Structure Correlation with Biocidal Activity

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A brief account is given of the synthesis, structural chemistry and the antibacterial, antifungal and cytotoxic effects of organotin complexes of 2-[(2,4-dichloroanilinocarbonyl)]benzoic acid. The unimolar and bimolar substitution products have been characterized by elemental analysis and spectral studies, including IR, [H NMR, 13C NMR, 119Sn NMR, and mass spectra. The data support the binding of the oxygen atom to the tin atom in [R2Sn(OOCR/>2] and [Rr.SnCOOCRי)] (R = Me, Bu, and Ph, R;= 2-[(2,4-dichloroanilinocarbonyl)]benzoic acid). Based on these studies, with a coordination number of four, a distorted tetrahedral geometry has been proposed for the resulting derivatives in solution. The free ligand (RיCOOH) and its respective tin complexes were tested in vitro against a number of microorganisms to assess their biocidal properties and to correlate them with the structures of the derivatives.

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