پديد آورندگان :
ZHANG SHIJUN نويسنده , CHEN GENXIN نويسنده , PENG CUI YING نويسنده , LAO SHAOXIAN نويسنده , LIN YOUWU نويسنده , CHEN ZEXIONG نويسنده , CHENG YONGHUA نويسنده
چكيده لاتين :
BACKGROUND: Most studies about aquaporin 3 (AQP3) in the gastrointestinal tract were carried out on both in vivo and
in vitro. The role of AQP3-mediated water transport in human gastrointestinal tract is still unclear. Our aim in this study
was to explore the expression of AQP3 gene in chronic atrophic gastritis (CAG) and chronic superficial gastritis (CSG)
patients and to determine its possible function in the development of gastritis.
METHODS: Twenty-two outpatients diagnosed as CSG and 12 outpatients diagnosed as CAG were selected randomly.
Ten cases of healthy individuals were selected as normal control group. In all cases, AQP3 gene expression of gastric
mucosa was detected by fluorescence quantitative polymerase chain reaction (FQ-PCR).
RESULTS: The AQP3 gene expression was significantly higher in gastric mucosa of CSG and healthy individuals than
that in CAG (P(LESS THAN)O.Ol). However, there was no significant difference in the AQP3 gene expression between helicobacter
pylori positive patients and helicobacter pylori negative patients (P>0.05).
CONCLUSIONS: AQP3 expression might play certain role in the occurrence and development of gastritis.
