پديد آورندگان :
ADIBI ATOOSA نويسنده , SIROUS MEHRI نويسنده , AMINORROAYA ASHRAF نويسنده , ROOHI EHSAN نويسنده , MOSTAFAVI MOHSEN نويسنده , Fallah Zahra نويسنده , TABATABAEI AZAMOSSADAT نويسنده , AMINI MASSOUD نويسنده
چكيده لاتين :
BACKGROUND: Because of different values of thyroid volume in different populations, and the effects of different trace
element and geographic substances on thyroid volume, we decided to evaluate thyroid volume and its determinants using
ultrasound in healthy adults of Isfahan, a centrally located city in Iran, an iodine replete area.
METHODS: In a cross-sectional study, 1500 healthy adults were enrolled by eluster sampling. Serum TSH level and
morning urine iodine level were measured. Thyroid exam was performed according to WHO criteria and history of previous
or present thyroid disease was taken. If all the mentioned results were normal they were considered clinically
normal. One third of these normal subjects referred for thyroid ultrasonography. If ultrasonography of thyroid parenchyma
texture was normal, and there was no nodule by sonography (thyroid incidentaloma), thyroid volume was measured
using ellipsoid formula (Xx YxZxa/ti). Correlation between thyroid volume and age, sex, BMI, TSH level and urinary
iodine concentration (UIC) was determined by Pearson correlation coefficient, t-Test and Kolmogorov-Smirnov.
Thyroid volume more than 97% ofthis population was considered as goiter sonographically, Data expressed as mean ±
SD, unless otherwise stated.
RESULTS: We finally studied 200 subjects (123 Males, 77 females, average age: 37.27 (PLUS-MINUS) 11.80 Years). The overall thyroid
volume was 9.53 (PLUS-MINUS) 3.68 m!. Males thyroid volume (10.73 (PLUS-MINUS) 3.44 ml) was significantly higher than the females one
(7.71 (PLUS-MINUS) 2.63 m!) (P(LESS THAN)O.OO I). The thyroid volume ranges were 3-23.9 ml, 3.6-23.9 ml and 3-14.3 ml in all, males and females,
respectively. Thyroid volume values more than 97 percentile ofthis reference range were 10.14 ml, 11.48 ml and
8.37 ml in all, males and females respectively, and were considered goiter sonographically. Thyroid volume had a positive
correlation with age (r = 0.163, P = 0.022). but did not have correlation with serum TSH, UIC, and 8MI, in both
sexes. There was a strong correlation between thyroid volume, and height and body surface area (r = 0.48. P(LESS THAN)O.OO I).
CONCLUSIONS: It was documented that thyroid volume is higher in male sex and increases with age, and have a positive
correlation with body surface area and height.