پديد آورندگان :
Abdi Khosrou نويسنده , Mandegary Ali نويسنده , Amini Mohsen نويسنده , Bagheri Mozhgan نويسنده , Gerami-Panah Farideh نويسنده
چكيده لاتين :
Acryli c base resins are widely used in orthopedics and dental surgery. It is generally
accepted that due to the incomplete conversion of methyl methacrylate (MMA) monomer to
the polymer form during polymerization of the resin, some MMA monomers remain in the
hardened material. MMA monomer has been reported to cause abnormalities or lesion s in
several organ s of animals. Study of the literatures showed that there are no perfect and valid
methods for analysis ofMMA. The aim of this study was to develop a simple and valid method
for determination of MMA residual monomer in the denture base resins.
We have developed and validated an analytical procedure employing gas chromatography
with flame ionization detector (GC-FID), with temperature programming, and a close analogue
intemal standard for fast and repeatable analysis of MMA residual monomer contents in
denture base polymers. For quantification of monomer, two calibration curves were used by
two diffe rent methods of solution preparation and they were compared to each other. The
assay was linear over the range of 0.03-0 .6 mg/ml MMA with correlation coefficients (r2) of
greater than 0.99. Accuracy, intra-day (Error<9.1%) and inter-day (Error<6.6%) , precision
(RSD<5.5% and RSD<6.5%, respecti vely) were in acceptable values over the examined
concentration range . Limit of detection (LOD) and limit of Quantification (LOQ) for MMA
were 0.0 I and 0.02 mg/ml , respectively. In conclusion, the propo sed method was a simple and
fast assay for MMA residual monomer in denture base resins.
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