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Hypoglycemic Activity of Casearia esculenta Roxb. in Normal and Diabetic Albino Rats

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The hypoglycemic effect of ethanolic extract of Casearia esculenta was investigated on alloxan induced diabetic rats. The blood glucose levels were measured at 0, 1,2 and 3 h after the treatment. The ethanolic extract of C. esculenta (250 mg/kg) reduced the blood glucose of normal rat from 85.50(PLUS-MINUS)1.22 to 64.67(PLUS-MINUS)3.27 mg/dl, 3 h after oral administration of the extract (P(LESS THAN)0.05). It also significantly lowered blood glucose level in alloxan induced diabetic rat from 331.67(PLUS-MINUS)4.90 to 130.33±6.53 mg/dl, 3 h after oral administration of the extract (P(LESS THAN)0.05). The antihyperglycemic activity of C. esculenta was compared with tolbutamide, an oral hypoglycemic agent.

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