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In vitro Anti-epimastigote Activity of some Iranian Medicinal Plants

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Some medi cinal plants are a potent ial source of new dru gs, in orde r to impro ve the treatment of Cha gas di sease whose treatment is still a challenge. In th is study, the in vitro anti -epimastigote acti vity of ce rta in fractions of Achillea biebersteinii, A. millefol ium, Saturej a mutica and S. macrantha was evalu ated . Diethyl ether fraction s of Achillea species and acetone fractions of Satureja species wer e the most active fraction s (MLC= 12.5 ug/ml) against the epimastigotes of Trypanosoma cruzi, the ethiological agent causing Chagas disease. The trypanocidal activity seems to be decreased by fractionation, using MeOH and water as the solvents. The result s obt ained from biological assay revealed that Achi llea and Satureja species could be a source of ac tive trypanocid al compounds .

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