17417

Protein Tyrosine Phosphatase-Like Protein Ia2 Antibodies and Clutamic Acid Decarboxylase 65 Antibodies (GADA) are not Associated With Sarcoidosis

Konstantinos Papadopoulos I. نويسنده , Goran Sundkvist نويسنده , Henrik Borg نويسنده , Bengt Hallengren نويسنده

147

150

4

T he existence of an association between glutamic acid decarboxylase 65 antibodies (GADA) and/or IA2 antibodies and sarcoidosis was evaluated. Materials and Methods: 78 patients with documented sarcoidosis, divided according to the presence (N=37) or absence (N=41) of autoimmune manifestations were evaluated for GADA and IA2 antibodies using, a radioligand assay with human recombinant 35S-labeled GAD65 and IA2 respectively. Results: Two patients with GADA (2.6%) and one (1.3%) with IA2ab, both in the group of patients with autoimmunity associated sarcoidosis were found. The GADA positive patient had manifest Type 1 diabetes that succeeded sarcoidosis. IA2 ab-positivity was seen among patients with isolated sarcoidosis. GADA and IA2ab frequencies were not increased compared to reference subjects (2-3%). Conclusions: No clear association between sarcoidosis and GADA and/or IA2ab was found. In patients with sarcoidosis, GADA seem to be associated with type 1 diabetes or other autoimmune manifestations rather than with sarcoidosis per se.

1201339