چكيده لاتين :
Background: The ability of the ovary to respond to exogenous gonadotrophin stimulation and
development of several follicles is essential in assisted reproductive technology. Neither age and
regularity of menses nor follicular phase FSH and estradiol concentrations are reliable predictors of
ovarian response. Day 3 serum inhibin-B level, during induction ovulation, has been proposed as a
predictor of ovarian response.
Objective: To determine day 3 serum inhibin-B as a predictor of ovarian response to induction ovulation
in IVF/ICSI cycles.
Materials and Methods: Seventy one infertile patients under 40 years old were enrolled in this study.
All women haveboth ovaries, basal FSHlevel under 15 mIU/ml, and no evidence of endocrine disorders.
Day 3 FSH, estradiol, inbibin-B concentrations and ovarian volume were measured before treatment. All
patients underwent standard long GnRH agonist protocol. The number of oocytes retrieved, fertilization
rate, clinical pregnancy rate, days of stimulation and number of HMG ampoules were determined. The
patients were divided into two groups, normal responders and poor responders (number of oocytes
retrived <4).
Results: The mean inhibin-B level in normal responders was 166.9± 141 pg/ ml versus 115.8 ± 87 pg/ml
in poor responders, which the difference was not statistically significant (p=0.24). Wecouldnot find a cut
offbetween nonnal andpoorresponders.
Conclusion: The use of day 3 inhibin-B level as a predictive marker of ovarian response in IVFIICSI
cycles is not reliable.
