چكيده لاتين :
A 75-year-old patient was referred with vaginal bleeding. Her
physical exam showed two flat dark plaques on the posterior
fourchette, mostly on left lateral side of the vulva, A black soft
mucosal nodule was present on the left lateral side of upper
vagina, and a polypoid ulcerative cervical lesion extended into
the right parametrium. Cervical and vaginal biopsies were in
favor of malignant melanoma, while vulvar biopsy was in favor
of lentigo maligna melanoma. The diagnosis was confirmed
using immunohistochemical studies with SI 00 and
HMB 45. The patient was treated by wide local excision of the
vulvar lesion followed by high-doses of fractionation radiotherapy
of the cervix and upper vagina. Due to advanced and
aggressive melanoma of the cervix, in comparison to the lentigo
maligna of the vulva, and the presence of vaginal melanomas
on the opposite site of the cervical lesion, it is suggested
that the origin of these two lesions are multi focal
rather than the direct extension.
