پديد آورندگان :
Ostad Seyed Naser نويسنده , Monsef-Esfahani Hamid Reza نويسنده , Taheri Samira نويسنده , Azizi Ebrahim نويسنده , Faramarzi Mohammad Ali نويسنده
چكيده لاتين :
Three major flavonoid fractions were separated from a methanol extract of
Calendula officinalis flowers by preparative TLC. These fractions were evaluated
for the inhibition of parent and tamoxifen resistant T47D human breast cancer
cells. We also examined the effect of quercetin and isorhamnetin on the growth of
parent and resistant T47D cells in the presence and absence of tamoxifen. It was found
that quercetin increased cell proliferation of the resistant T47D cells at the presence
of tamoxifen but no effect was detected by using quercitin alone. The fractions isolated
from Calendula officinalis did not show any inhibitory effects on the cells.
Isorhamnetin did not have any proliferative or anti-proliferative activity on the both
cell lines.
