چكيده لاتين :
In order to investigate the effects of dimethylamino substituent at postion 2
of the dihydropyridine nucleus on its activity, dialkyl 1,4-dihydro-2-[2-
(dimethylamino) ethyl]-6-methyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,
5-pyrdinedicarboxylates (6a-f) were synthesized. The synthesis was started from
dialkyl 1,4-dihydro-2,6-dimethyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-
pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel
antagonist on guinea-pig ileum has been reported previously. Rabbit jejunum was
used to determine the relaxant or antagonistic activity of the synthesized compounds.
Some of the compounds (6c-e) inhibited the spontaneous contractile activity of
jejunum, dose-dependently and completely, while high-K+ contracted tissues were
relaxed partially.
