چكيده لاتين :
Since the incidence of symptomatic congenital cytomegalovirus infection is low (~0.05%)
and risk factors are not well defined, it is difficult to develop strategies for prevention. The
aim of this study was to recognise the utility of specific Immunoglobulin G avidity analysis
for distinguishing primary infection from past/recurrent infection.
Sera from 50 women with cytomegalovirus specific Immunoglobulin M antibodies
without proven seroconversion and infants born to these women were tested for presence of
Immunoglobulin M antibodies by commercial enzyme immunoassay.
For cytomegalovirus specific immunoglobulin G avidity, sera were measured by
commercial kit according to manufacturerיs recommendations.
Among 50 sera form mothers, 26 showed the presence of Immunoglobulin M antibodies
out of which 15 had low avidity antibodies. Out of 50 sera from children, 18 showed the
presence of Immunoglobulin M antibodies. Out of these 18 sera from children, 12 were
symptomatic, which all showed the presence of low avidity antibodies.
The results showed that an avidity index (LESS THAN)40% and presence of Immunoglobulin M
antibodies is highly suggestive of a recent primary infection.
