چكيده لاتين :
Background: Arterial hypertension is an important risk factor for coronary artery disease and
cardiovascular-induced morbidity and mortality. It can cause end-organ damages such as
cerebrovascular diseases, renal failure, and congestive heart failure. On the other hand, because of
elevated blood pressure and rapid blood flow, there is an increase in oxidation and peroxidation
reactions. The aim of this study was to evaluate the level of oxidized low-density lipoprotein and
superoxide dismutase activity in sera of hypertensive patients.
Methods: In this case-control study, 70 hypertensive patients without any other important
diseases such as congestive heart failure, cardiomyopathy, liver disease, diabetes mellitus, renal
disease, or thyroid disease were compared with 70 age-and gender-matched controls. The
participantsי age range was from 30 to 75 years. Measurement of oxidized low-density lipoprotein
in serum was performed by enzyme-linked immunosorbent assay. The activity of superoxide
dismutase in serum was measured by enzymatic colorimetry method.
Results: The patientsי mean age±SD was 52.2±14 years. The controlsי mean age±SD was 45±13
years. The level of superoxide dismutase activity in the patientsי group was 100±27 U/mL, and in
the controls’ group was 105±11 U/mL. The level of oxidized low-density lipoprotein in the patientsי
group was 14±4 mu/L, and in controls it was 7.7±3 mu/L.
Conclusion: Data of this study demonstrated an elevation of oxidized low -density lipoprotein
in hypertensive group that may be the result of oxidation processes. Superoxide dismutase activity
was decreased in hypertensive patients, which can be the result of elevated oxidation reactions.
