عنوان به زبان ديگر :
Synthesis, Characterization, and Drug Release Behaviour of Novel Soy Protein/Poly(acrylic acid) IPN Hydrogels
پديد آورندگان :
Liu Yong نويسنده , Cui Yingde نويسنده , Yin Guoqiang نويسنده , Ma Hanchong نويسنده
چكيده لاتين :
Aseries of novel interpenetrating polymer network (IPN) hydrogels based on soy
protein (SP) and poly(acrylic acid) (PAA) were prepared with glutaraldehyde and
N,Nי-methylenebisacrylamide (BIS) as the cross-linking agents. The structure
and properties of the IPN hydrogels were characterized by FTIR, SEM, and DSC. The
effects of pH and SP and BIS contents on the behaviour and release mechanism of the
model drug bovine serum albumin (BSA) were also investigated in detail. The FTIR
data indicated that the absorption of BSA into the IPN hydrogels is purely physical
process. The SEM showed that changing the content of SP or BIS can influence the
pore size and pore wall thickness of the hydrogels. The DSC data signify that all the
hydrogels had good compatibility and miscibility, as well. It was also found that the
release profiles of BSA strongly are dependent on the value of pH. The release percentage
of BSA decreased with increasing the contents of SP or BIS. The BSA release
profile followed Fickian diffusion pattern at pH below the pKa of PAA and the non-
Fickian diffusion at pH above the pKa of PAA. The results showed that the IPN hydrogels
are suitable candidates for colon drug delivery.
