پديد آورندگان :
Wei Changzheng نويسنده , Hou Chunlin نويسنده , Gu Qisheng نويسنده , Jiang Lixia نويسنده , Zhu Bin نويسنده , Sheng Ailian نويسنده
چكيده لاتين :
post-operative adhesions are an unavoidable and serious complication, which
can cause severe pelvic pain, infertility and bowel obstruction. Many pharmacological
and macromolecular polymers have been tested for adhesion prevention.
Recently, physical barriers have greatly attracted peopleיs attention. In this paper, we
study the efficacy of thermosensitive hydroxybutyl chitosan (HBC) in prevention of
post-operative abdominal adhesions, using a rat side-wall defect-cecum abrasion
model. HBC is a new derivative of chitosan whose main character is the intelligent
response to changing temperature. HBC was prepared through chemical modification
of 1,2-butylene oxide, whose molecular weight was higher than other reported products.
The lower critical solution temperature was established as 20؛C at a concentration
of 1% (w/w). When injected into the abdomen, HBC solution formed flexible hydrogels
within 30-60 s. A durable physical barrier was formed between the defective cecum
and the abdominal side-wall. Eight out of 10 animals in the control group developed
adhesions with a score of 3, while only one of 10 animals treated with HBC showed
such adhesions. Compared with non-cross-linked hyaluronic acid, HBC demonstrated
more anti-adhesive activity. Furthermore, HBC was easy to handle during operation.
Therefore, it may be effective in prevention of post-operative adhesions.
