چكيده لاتين :
Aqueous and acetone extracts of Garcinia kola seeds were screened for activity against 27 bacterial isolates at 30 and 10 mg mL?1, respectively. The aqueous extracts showed activity mainly against Gram positive organisms with MIC values ranging from 5-20 mg mL?1. The acetone extract showed activity against both Gram negative and Gram positive organisms with MIC values ranging from 10-0.156 mg mL?1. The bactericidal activity of the acetone extract was evaluated against Staphylococcus aureus ATCC6538 and Proteus vulgaris CSIR0030 by time kill assay. The extract showed rapid bactericidal activity achieving a 3.097 log10 reduction in counts within 4 h at 0.3125 mg mL?1 against Staph. aureus ATCC6538 and complete eradication of the organism in 8 h at 2? and 3? MIC levels. A 1.582 log10 reduction in counts was observed against P. vulgaris CSIR0030 at 5 mg mL?1 after 1 h of exposure and a complete eradication was observed in 2 h. We propose that acetone extract of Garcinia kola seeds possess strong bactericidal activities and can be chemotherapeutically useful in the treatment of bacterial infections in humans.
