عنوان به زبان ديگر :
Study on the Frequent Expression of Rodgers and Chido, Red Blood Cell Antigens, in Iranian Healthy Population
پديد آورندگان :
Sharifi Zohreh نويسنده , Mahmoudian Shooshtari Mahmoud نويسنده , Yari Fatemeh نويسنده , Sabaghi Fatemeh نويسنده , Zaman Vaziri Maryam نويسنده , Sobhani Maryam نويسنده
چكيده لاتين :
Rodgers (Rg) and Chido (Ch) are blood-group antigens and they determine the fourthcomponent
of human complement C4. Rodgers and Chido are associated with two C4
isotypes (C4A and C4B). In addition to genotype determination, study on expression of
Rg and Chido could be useful in disease studies.
DNA was extracted from the whole blood of 60 normal individuals. Then, PCR amplification
of C4d gene fragment was followed by restriction digestion. This study
demonstrated that the frequency of Ch and Rg in Iranian healthy population was
98.3 and 93.4 percent, respectively. Additionally, 6.6 percent of the studied population
showed Chido-positive, Rodger-negative and 1.7 percent showed Rodger-positive,
Chido-negative genotype. It may be concluded that upon receiving blood transfusion,
6.6 and 1.7 percent of individuals could produce anti-Rg and anti-Ch antibodies, respectively.
