قياس بعض المتغيرات الكيموحيوية المرتبطة بوظائف الكبد و الكلية في مصل دم الاطفال المصابين بالثلاسيميا

This study aims at recognizing the negative effects of Thalassemia disease, on the functions of both the kidney and liver. The research constitutes 40 patients with the age of (5-10) years old in addition to 15 children as a control group having the same age range. The biochemical parameters have measured the liver function represented by measuring the effectivity of liver enzyme aminotransferase (Aspartate aminotransferase AST” and Alanine aminitransferase “ALT”), in addition to the measurement of serum total protein, bilirupine, urea and albumin. Kidney function is measured through including uric acid and creatinine. The results of the study have shown a decrease in the total protein concentration in the serum of blood at the level of (6.16 ± 0.1 p < 0.05) in male children compared with the control group level which is (8.7 ± 0.7 p < 0.05), the urea concentration has shown an increase the serum of male children as (47.4 ± 4.8 p < 0.05) compared with the level for the control group which is(35.2 ± 3.5 p < 0.05), enzymes Alanine aminitransferase and Aspartate aminotransferase show an increase in the serum of both (male and female) children which is (26.42 ± 1.6,48.9 ± 2.9 p < 0.05) and (23.81 ± 2, 42.7 ± 3.6 p < 0.05), respectively, compared with the control group level which is (33.2 ± 4.3 p < 0.05) and (18.5 ± 2.3 p < 0.05), uric acid increase in the serum of (male and female) children blood has reached (8.32 ± 0.9 p < 0.05) and (8.5 ± 0.6 p < 0.05), respectively, compared with the control group level which are(7 ± 1.1 p < 0.05)and (6.3 ± 0.23 p < 0.05)