Synthesis of 2-aryl-1H-perimidine derivatives by reaction of 2-benzylidenemalononitriles and naphthalene-1, 8-diamine

2-Aryl-1H-perimidines is a synthetic tricyclic compounds including double nitrogen atom on its structures. These chemical compounds and its analogs have been described as DNAintercalating and antitumoral agents against several carcinogenic cell lines[1-3]. 2-Phenyl-1H-perimidine is readily prepared, in high yield, by refluxing a mixture of 2- benzylidenemalononitrile and 1, 8- diaminonaphthalene in water. This reaction leads to products 3, 4. The structure of these productswere proved by 1H-NMR, 13C-NMR and IR spectral data( Figure 1).