چكيده فارسي :
The synthesis of bis(indolyl)methanes has become the center of interest among world
scientists due to their wide spectrum of pharmacological and biological applications. They
have achieved a considerable importance as key moieties having extensive applications in
medicinal and biological chemistrysuch as the inhibition of cancer cell growth through the
induction of apoptosis and metastasis [1].These different pharmaceutical and biological
applications have caused the development of a number of methods for the synthesis of
bis(indolyl)methanes by the electrophilic substitution of indole with the various aldehydes in
the presence of the different catalysts [2,3].
In recent years, ionic liquids as solvent or catalyst have attracted significant attention due
to their peculiar properties including low vapour pressure, excellent thermal and chemical
stability, tunable polarity, high ionic conductivity and immiscibility with certain organic
solvents. In addition, the widespread range of possible cation and anion combinations
represents the various applications and tunable interactions [4].
In this study, butylammonium hydrogen sulphate [(BA)(HSO4)] was synthesizedas a
ammonium-based ionic liquidvia a simple chemical routein water. The [(BA)(HSO4)] ionic
liquid was successfully applied as an eco-friendly and recyclable catalyst for the synthesis of
bis(indolyl)methane derivatives at room temperature under solvent-free conditions. Taking
the environment and economy into consideration, the work presented here has the merits of
environmental friendliness, high yields, simple work-up, easy operation and the avoidance of
the organic solvents and inexpensive catalysts.
