پديدآورندگان :
Eydipoura Zainab Department of Biology, Damghan Branch, Islamic Azad University, Semnan, Iran , Vaezia Gholam-Hassan Cognitive and neuroscience research center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran , Nasehib Mohammad Department of Animal Biology, School of Biology, University College of Science, University of Tehran, Tehran, Iran , Haeri-Rouhani Seyed-Ali Department of Animal Biology, School of Biology, University College of Science, University of Tehran, Tehran, Iran , Zarrindastb Mohammad-Reza d Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
كليدواژه :
Sleep , Hippocampus , CA1 , 5HT4 , Memory
چكيده فارسي :
1. Background and aim: Sleep is a circadian or daily biologic rhythm which is modulated through an endogenous circadian clock located in suprachiasmatic nucleus (SCN). Sleep primarily promotes memory consolidation while memory coding and retrieval can occur effectively during wakefulness. Several studies have shown that sleep deprivation can affect cognitive functions such as memory, learning, and motor activities. 5 HT4 receptors are mainly expressed in hippocampus and it has been observed that they play a distinguished role in behaviors such as anxiety, learning, and memory processes. The present study aims to investigate the effects of activation and inactivation of serotonin 5HT4 receptor by RS67333 (agonist serotonin-4 receptor) and RS23597 (antagonist serotonin-4 receptor) in CA1 on acquired memory impairment induced by REM sleep deprivation (RSD: 24 hours). Method: Multi-platform apparatus was applied to induce RSD. Passive avoidance memory test was used to evaluate memory consolidation. Results: Intra-CA1 pre-training injection of both RS67333 and RS23597 in doses of 0.1 and 0.01 mg/rat decreases motor activities but doesn’t have any effects on pain. RSD decrease acquisition memory. But doesn’t affect motor activities or pain. However, regarding RSD conditions, RS23597 but not RS67333 improve RSD-induced acquisition memory deficit with sub-threshold dose. However, both drugs are ineffective regarding motor activities and RSD-induced pain.Conclusion: According to our findings, it seems that CA1 5HT4 receptors play a critical role in cognitive and non-cognitive behaviors induced by RSD.
