Glucose: an efficient catalyst for one-pot multi-component synthesis of bis(pyrazol-5-ols) in an environmentally benign manner

Th e biologically important bis(pyrazol-5-ols) synthesized by an efficient and convenient approach for one-pot, pseudo five-component coupling of hydrazine monohydrate, ethyl acetoacetate and aldehydes in the presence of a catalytic amount of glucose as an efficient, inexpensive and environmental friendliness catalyst. Th e merits of this reaction are higher product yields in shorter reaction time and environmentally benign reaction conditions.