شماره ركورد كنفرانس :
4518
عنوان مقاله :
Mathematical modeling of biodegradable drug delivery systems
Author/Authors :
H Heidari Dept. Chem. Eng - University of Sistan and Baluchestan, Zahedan , M Khorram Dept. Chem. Eng - University of Sistan and Baluchestan, Zahedan , A Samimi Dept. Chem. Eng - University of Sistan and Baluchestan, Zahedan , N Mehranbod School of Chemical - Petroleoum and Gas Engineering - Shiraz University, Shiraz
كليدواژه :
drug delivery , polymer degradation , mathematical model , poly(lactic acid)
عنوان كنفرانس :
The 7th International Chemical Engineering Congress & Exhibition (IChEC 2011
چكيده لاتين :
The present study was carried out to develop a general transport-reaction mathematical model for describing simultaneous biodegradation and drug release from drug-loaded biodegradable polymers. To develop proposed model, the water penetration into the devices, catalyzed and un-catalyzed hydrolysis reactions, and monomer diffusion out of the matrices during drug release process was considered, and Fick’s law was used. The developed model are solved numerically. Parametric studies are carried out using the model to demonstrate the effects of catalyzed and un-catalyzed hydrolysis rates on the degradation and drug release rate. Finally, model was fitted to experimental data reported in literature. The results of model computation agreed well with the experimental data.
