Zeolite-MnFe2O4: as a novel and highly¬ efficient catalyst for the synthesis of 1,5-benzothiazepine derivatives under solvent free condition

1,5-Benzothiazepines have attracted as an important class of heterocyclic compounds in the field of drug and pharmaceutical research. These compounds are widely used as anticonvulsant, analgesic, sedative, antidepressive, antibacterial, hypnotic agents as well as anti-inflammatory agents. In the present study, An efficient synthesis of new derivatives of 1,5-benzothiazepine has been developed by the reaction of various chalcones (1,3-diaryl-2-propenones) with 2-amino-thiophenol in the presence of Zeolite-MnFe2O4 catalyst without solvent. First, the natural zeolite is activated under appropriate conditions. Then, manganese ferrite were synthesized by reaction of Fe2 (SO4) 3.H2O with MnCl2 and placed on the surface of activated nano zeolite. Under optimized reaction conditions, various 1,5-benzothiazepine derivatives were synthesized and the products were obtained with good to excellent yields and high purities. Ambient reaction temperature, Short reaction times, easy work-up, reusability of the catalyst and no use of harmful organic solvents are among the most important characteristics of the present methodologies. The structures of the synthesized compounds were confirmed by IR, SEM, EDAX and NMR analysis.