Effect of Cholinium Bi-Tartrate as a Biocompatible Salt on the Volumetric, Acoustic and Viscometric Properties of Aqueous Diphenhydramine Solutions

Cholinium-based carboxylic acid are known as novel, low toxic and biocompatible salts which are used widely in biotechnological and pharmaceutical processes [1-3]. In these processes, the role of used salt is more effective on the interactions between drug and water [4, 5]. These interactions can be effected on the thermodynamic and transport properties correspond to drug. In this respect, the aim of this work is to investigate of cholinium bi-tartrate ([Ch][bit])-diphenhydramine interactions in water media by measuring of density and speed of sounds for the mentioned ternary solutions at T = (288.15 to 318.15) K under atmospheric pressure. The obtained values from this study were used to calculate the limiting molar volume ( ∆t Ҡᵩ0 ), limiting molar compressibility (Ҡᵩ0 ), transfer molar volume ( ∆tVᵩ0 ), transfer molar compressibility, and hydration number (nH ). Also, viscosity values for the above mentioned solutions were measured. Then, these values were utilized for calculating of viscosity B-coefficients which provide a useful information about water structure in presence of the [Ch][bit] and drug.