Interaction of Polyphenols with Nerve Growth Factor: A Docking Studies

Polyphenols are an important group of phytochemicals that are found in food sources. Flavonoids are large group compounds of polyphenols that are used in diagnosing and treating certain diseases. In this study, Baicalein(BCL) and Isoharmentin(IHN) was optimized and they have docked to nerve growth factor by genetic algorithm. Results show they have less binding energy and best interaction and more inhibitory constant. It means they can inhibits NGF and they have anti-aging properties.