Investigation of DNA Interaction with Two New Platinum(II) Complexes

Two new Pt(II) complexes were synthesized and their structure details were investigated by different spectroscopies methods. Interaction of the Pt(II) complexes were investigated with calf thymus DNA (CT-DNA) by UV-Vis, photoluminescence and viscosity measurements. The binding constants containing Kb and Kf were calculated and the obtained data were compared with each other. The spectra of emission and absorption increased upon addition of DNA. Moreover, thermodynamic parameters of the interaction between Pt(II) complexes and DNA were calculated. The positive changes of enthalpy and entropy proved hydrophobic interaction.