The use of chemometrics methods for analyzing the simultaneous release of drugs from the polymeric substrates

Most recently, significant medical advances have been made in the area of drug delivery with the development of controlled release dosage forms using various types of polymers as substrates for drug loading, but these improvements have not been completely defective. The development of mathematical models is widely employed in different disciplines and are very useful in the case of controlled drug delivery systems as this approach enables, the prediction of release kinetics before the release systems are to be realized. Often, it delivers the measurement of some important physical parameters, such as the drug diffusion and the other parameters. (1- 4) Treximet is a combination drug for the treatment of an acute migraine, Which is a combination of Sumatriptan, and naproxen sodium drugs. In this study, we used melamine-modified poly(styrene-alt-maleic anhydride) to load and release the so-called drugs. The modified polymer matrices were studied by FT-IR spectroscopy. The release of these drugs was monitored separately and in different pH by the UV-vis spectroscopy. pH=6 is chosen as the optimal pH. In order to study the release kinetics, experimental data obtained from in vitro drug release were approximated by several mathematical models including zero-order, first-order, Hixson-Crowell and Korsmeyer-Peppas to determine the kinetics of drug release from drug delivery systems. The obtained results showed that the Korsemeyer–Peppas model fits well the data of Sumatriptan and Naproxen release. Also it has been shown that the release kinetics for both drugs are similar for simultaneous and single drug release studies and the obtained mathematical models can be used in both situations.