Electrochemical determination of acetaminophen by using modified screen printed carbon electrode

In the present work, a rapid and sensitive detection of the acetaminophen (AC) based on the modified screen printed carbon electrode (MSPCE) developed. Cyclic voltammetry was used to study the electrochemical behavior of AC and its determination was conducted by applying square wave voltammetry (SWV). The MSPCE in comparison with bare SPCE exhibited enhanced electrocatalytic activity toward the oxidation of AC. A single irreversible oxidation peak was observed at a potential of 590 mV and 480 mV on the MSPCE and bare SPCE, respectively. Under the optimized conditions, the anodic peak current of AC recorded by SWV varies linearly with AC concentration in the range 0.5–220 µM with a detection limit of 0.1 µM. The MSPCE was used for quantitative analysis of AC in AC ampule and AC tablet samples and the results indicate the feasibility of the amperometric method for AC analysis in routine detection.