Nanostructure Silica Aerogels as Drug delivery Systems

فاقد چكيده فارسي

Silica aerogels are loaded with a model drug as drug delivery systems. The drug loading procedure is carried out on silica aerogels with adsorption in ambient condition. Hydrophobic and hydrophilic silica aerogels are loaded from drug solutions in ethanol and propanol. The obtained drug-aerogel formulations are characterized with FT-IR and UV-vis spectroscopy. Drug Release kinetics of the drug-aerogel formulations and pure drug were also evaluated. The results show that the drug molecules are successfully loaded on aerogels in this method, and drug loading on hydrophobic silica aerogels is higher than the hydrophilic one. As well as drug loading of its solution in ethanol is higher. The release rate of drug- hydrophilic silica aerogel formulation is faster than that of pure drug. The reasons for this development are increase in the specific surface area of the drug adsorbed on the aerogel and the fast collapse of hydrophilic aerogel network in aqueous media. In the case of hydrophobic silica aerogel-drug formulation, drug release rate decreased which is due to stability of this aerogel network in aqueous media that controlled the release rate with drug diffusion in the network. Drug loading on hydrophilic silica aerogel improve the dissolution rate of poorly water soluble drugs. Also using the hydrophobic silica aerogel controls the release rate of drugs in special application of drug delivery systems that controlled release of drugs is appropriate.