شماره ركورد كنفرانس :
5048
عنوان مقاله :
Effect of functionality of pressure sensitive adhesives on in vitro evaluation of a double layer fentanyl patch
Author/Authors :
Mojtaba ،Taghizadeh Novel DrugDelivery Systems Department - Science Faculty - Iran Polymer and Petrochemical Institute - Tehran, Iran , Arezou ،Soroushnia Novel DrugDelivery Systems Department - Science Faculty - Iran Polymer and Petrochemical Institute - Tehran, Iran , Fatemeh ،Mohamadnia Novel DrugDelivery Systems Department - Science Faculty - Iran Polymer and Petrochemical Institute - Tehran, Iran
كليدواژه :
fentanyl , transdermal drug delivery system , skin permeation , pressure sensitive adhesive , peel strength , tack
عنوان كنفرانس :
ششمين كنگره بين المللي مهندسي شيمي
چكيده لاتين :
In this study double-layer transdermal drug delivery systems (TDDSs) with different functional and non-functional
acrylic pressure sensitive adhesives (PSAs) were prepared. For this purpose fentanyl as a drug was used. The effects of
PSAs type on skin permeation and in vitro drug release from devices were evaluated using a hydrodynamicly wellcharacterized
Chien permeation system fitted with excised rat abdominal skin. as well as the adhesion properties of
devices such as peel strength and tack values were obtained. It was found that TDDS with –COOH functional PSA
showed the lowest steady state flux. Double-layer TDDSs had the constant flux up to 72h. Drug release followed the
Higuchi's kinetic model. The double layer TDDSs with non-functional PSA demonstrated the suitable skin permeation
rate close to Duragesic®TDDS and suitable adhesion properties.
