شماره ركورد كنفرانس :
5048
عنوان مقاله :
Improvement of Acetaminophen solubility in supercritical carbon dioxide Using Menthol cosolvent
Author/Authors :
J ،Karimi Sabet Chemical Engineering & Petroleum DepartmentSharif - University of Technology - Tehran, Iran , C ،Ghotbi Chemical Engineering & Petroleum DepartmentSharif - University of Technology - Tehran, Iran , A ،Khanchi Chemical Engineering & Petroleum DepartmentSharif - University of Technology - Tehran, Iran
كليدواژه :
Acetaminophen , Menthol , solubility , poorly soluble drug , supercritical carbon dioxide
عنوان كنفرانس :
ششمين كنگره بين المللي مهندسي شيمي
چكيده لاتين :
In this work, the effects of Menthol cosolvent addition on the solubility of Acetaminophen (AC) in supercritical
carbon dioxide (SC-CO2) were investigated at temperature 313 K for pressures from 100 to 250 bar. Measurement of
solubility values under different pressures revealed that Menthol enhances the solubility of AC significantly. The
experimental data are useful to the production of ultra fine AC particles by RESS-SC method.
